一位接受泛慕马布治疗的患者的耳状口腔炎
Maria Kouri1, Erofili Papadopoulou1, Styliani Tziveleka1
1Department of Oral Medicine & Oral Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, AthensGreece.
Journal of oral & maxillofacial research
|February 28, 2025
概括
帕尼图穆马布 (Panitumumab) 是一种抗上皮生长因子受体抗体,可引起罕见的口服副作用,如类似于口腔炎的口腔炎. 用德克萨米他和特拉马多尔及时治疗有效地控制了症状,允许继续癌症治疗.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 口腔医学是指口腔医学.
背景情况:
- 帕尼图穆马布是一种抗表皮生长因子受体 (EGFR) 单克隆抗体,用于转移性结直肠癌.
- 虽然皮肤毒性很常见,但很少报告与巴尼穆马布相关的口服不良事件.
- 这份病例报告详细介绍了帕尼图穆马布诱导的口类似的口炎.
研究的目的:
- 报告患者患有类似口腔炎的口腔炎病例,该病例是用panitumumab治疗的.
- 突出 EGFR 抑制剂口服不良事件的可能性.
- 为了证明有效管理与panitumumab相关的口腔炎.
主要方法:
- 一名58岁的患有转移性结肠癌的女性患者接受了潘蒂图穆巴,义诺他干和5-甲.
- 患者出现了严重的口腔疼痛和类似口腔的.
- 治疗包括局部用德克萨米他和口服用特拉马多尔来治疗疼痛.
主要成果:
- 临床检查显示,在舌头,嘴唇,口腔粘膜和软上出现了多个类似口腔的.
- 局部用德克萨米他松和口服的特拉马多尔在一周内显著缓解疼痛和治愈.
- 帕尼图穆马布治疗继续没有中断.
- 在四个月的随访期间,没有观察到口腔症状的复发.
结论:
- 抗EGFR药物可能会导致严重的口服不良事件,影响生活质量和治疗遵守.
- 早期诊断,适当的治疗和密切监测对于接受抗EGFR治疗的患者至关重要.
- 这一案例证明了与panitumumab相关的口腔炎的成功管理,允许不间断的癌症治疗.
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