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Updated: May 25, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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基醇作为m6ARNA结合蛋白YTHDF2的抑制剂

Xiaqiu Qiu1,2,3, Claus Kemker1,2,3, Georg L Goebel1,2,3

  • 1Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany.

JACS Au
|February 28, 2025
PubMed
概括

研究人员发现了新的pyrazole化合物,如CK-75,可以抑制YTHDF2,这是RNA修饰中的关键蛋白质. 这些抑制剂通过阻止癌细胞生长和促进细胞死亡,显示出癌症治疗的潜力.

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