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在mThy1-α-synuclein小鼠中解读运动功能障碍和微质激活:对行为,基因表达和甲基化变化的全面研究

Brett A McGregor1, Md Obayed Raihan1,2, Afrina Brishti1

  • 1Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, United States.

Frontiers in molecular neuroscience
|February 28, 2025
PubMed
概括

在同核蛋白病变的进展过程中,微质谱的形状会发生变化. 早期的亲炎性反应以后过渡到受抑制的途径,表明在疾病中发挥了动态作用.

关键词:
通过DNA甲基化.在RNA-seqqq.这是一种α-synuclein.表观遗传学是指表观遗传学.微质细胞中的微质细胞综核蛋白异常症 (synucleinopathy) 是一种同核蛋白异常症.系统生物学 系统生物学转录组 (transcriptome) 是一个转录组.

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