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结合淋巴结冲洗液中的甲状腺蛋白水平与TI-RADS,预测乳腺甲状腺癌中的淋巴结转移

Xueni Lu¹, Ying Dang², Blessed Kondowe³

¹Nuclear Medicine Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.

Malawi medical journal : the journal of Medical Association of Malawi

|February 28, 2025

概括

淋巴结吸收中的甲状腺蛋白水平可以预测状甲状腺癌 (PTC) 患者的宫淋巴结转移. 这一发现对具有较大的结节的PTC患者尤为重要.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
诊断成像诊断成像诊断成像

背景情况:

乳头甲状腺癌 (PTC) 是最常见的甲状腺癌类型.
宫淋巴结转移是PTC的常见并发症,影响预后和治疗.
精确预测淋巴结转移对于有效的患者管理至关重要.

研究的目的:

为了研究淋巴结吸入洗液中的甲状腺蛋白 (Tg) 水平和甲状腺成像报告和数据系统 (TI-RADS) 结节分数对PTC患者宫淋巴结转移的预测值.
为了确定BRAF V600E基因突变状态是否会影响淋巴结转移.

主要方法:

分析了251名经过手术确认的PTC患者的队列.
术前评估包括TI-RADS分类的超声波,用于检测BRAF V600E突变的细针吸收活检 (FNAB) 和淋巴结吸收中的Tg测量.
统计分析,包括二进制物流回归,用于评估预测因素.

主要成果:

宫淋巴结转移发生在52.59%的患者中.
淋巴结吸附Tg水平在转移患者 (324.94 ± 192.52 ng/mL) 与没有转移患者 (67.93 ± 136.62 ng/mL) 相比显著更高 (P = 0.000).
淋巴结吸附Tg显示出良好的预测值 (AUC = 0.858),而BRAF V600E突变状态和TI-RADS评分没有显示出显著的预测影响 (P > 0.05).

结论:

淋巴结吸入的甲状腺蛋白水平是PTC中宫淋巴结转移的重要预测因素.
这种生物标志物对于预测PTC患者的转移特别有价值,因为PTC患者的结核较大.
在这项研究中,血清Tg水平和TI-RADS得分并不是显著的预测因素.

关键词:

宫淋巴结转移的发生.乳头甲状腺癌是一种乳头甲状腺癌.甲状腺球蛋白是一种甲状腺蛋白.甲状腺成像报告和数据系统超声波超声波是指超声波的使用.

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