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Updated: May 25, 2025

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在Graves的轨道病变中,PDK2增强的糖解通过IL11信号通路加剧纤维化

Zhiyu Peng1,2,3,4, Rui Huang1,2,3, Lu Gan1,2,3

  • 1Department of Ophthalmology, Fudan Eye & ENT Hospital, Shanghai, China.

Frontiers in immunology
|February 28, 2025
PubMed
概括

由酸盐脱酶激酶2 (PDK2) 驱动的增强糖解,通过11 (IL11) -IL11Rα通路恶化了Graves的轨道病变 (GO) 纤维化. 用二乙酸 (DCA) 抑制糖解显示出对GO的治疗潜力.

关键词:
格雷夫斯的轨道病变葡萄糖溶解是什么介质氨基-11 介质氨基-11 介质氨基-11轨道纤维母细胞细胞.转化生长因子β1的转化生长因子β1

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