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单细胞衍生的朗格汉斯细胞表达Delta-like 4诱导的tidoglycan和interleukin-4介导的抑制

Rei Ono1, Kohei Maeda1, Toshihiro Tanioka1

  • 1Department of Pathogenesis and Translational Medicine, Showa University Graduate School of Pharmacy, Tokyo, Japan.

Frontiers in immunology
|February 28, 2025
PubMed
概括

单细胞衍生的朗格汉斯细胞 (Mo-LCs) 表达德尔塔样4 (DLL4) 并强烈激活T细胞. 它们的诱导需要DLL4,GM-CSF和TGF-β1,为免疫疗法和自身免疫疾病研究提供了洞察力.

关键词:
类似三角洲的11类似三角洲的4 4兰格拉汉斯细胞是一种细胞.一个T细胞细胞.自身免疫性疾病 自身免疫性疾病一个单细胞单细胞.牛皮是一种牛皮.这是一种类似收费的受体.

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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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