卡塔尔糖尿病前期风险评分的现实世界临床验证:一个横截面研究
Narjiss Sallahi1, Abduljaleel Abdullatif Zainel1, Halima None Bensmail2,3
1Primary Health Care Corporation, Doha, Qatar.
BMJ public health
|February 28, 2025
概括
卡塔尔糖尿病前期风险评分 (PRISQ) 有效地识别了2型糖尿病 (T2D) 风险较高的个体. 这一验证得分显示,在40岁及以上的成年人中检测糖尿病前期的灵敏度超过90%,有助于早期干预.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 临床诊断 临床诊断 临床诊断
背景情况:
- 糖尿病前期是2型糖尿病 (T2D) 的重要风险因素,每年5-10%的糖尿病进展.
- 早期发现前糖尿病对于干预和预防T2D至关重要.
- 生活方式干预已被证明是有效的预防T2D从糖尿病前期的进展.
研究的目的:
- 在现实临床环境中验证卡塔尔糖尿病前期风险评分 (PRISQ).
- 评估PRISQ在卡塔尔人口中糖尿病前期的诊断准确性.
- 评估PRISQ在识别需要干预以预防T2D的个体中的实用性.
主要方法:
- 从初级卫生中心招募了1021名没有已知的糖尿病或糖尿病前期的随行参与者.
- 收集了人口统计数据,临床测量和家族病史.
- 测量血红蛋白A1c (HbA1c) 水平以诊断糖尿病前期 (5.7%-6.5%) 和未诊断的糖尿病 (≥6.5%);分析PRISQ的性能.
主要成果:
- 在提供血液的797名参与者中,21.9%患有糖尿病前期,3.3%患有未诊断的糖尿病.
- 在40岁及以上的个人中,PRISQ在检测糖尿病前期的敏感度超过90%,不论种族.
- 糖尿病的家族史并没有显著改善PRISQ的敏感性.
结论:
- 在现实世界的卡塔尔临床环境中,PRISQ是诊断糖尿病前期的有效和有效工具.
- PRISQ可以帮助早期识别糖尿病前期的个体,促进及时干预.
- 该得分有可能有助于缓解卡塔尔和全球不断增长的T2D流行病.
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