关节高移动性与自我报告的COVID-19不恢复有关吗? 来自英国COVID症状研究生物库的病例控制证据
Jessica A Eccles1,2, Dorina Cadar1, Lisa Quadt1,2
1Department of Clinical Neuroscience, Brighton and Sussex Medical School, Brighton, UK.
BMJ public health
|February 28, 2025
概括
综合性关节高移动性 (GJH) 与不从COVID-19中恢复的更高风险有关. 这种情况也预测了疲劳水平的增加,这可能会调解不恢复的结果.
科学领域:
- 结合组织疾病 结合组织疾病
- 传染病的流行病学传染病的流行病学.
- 长期COVID研究研究
背景情况:
- 综合性关节多动性 (GJH) 是连接组织变异的常见指标.
- 了解COVID-19无法恢复的风险因素对于公共卫生至关重要.
- 识别患有长期症状的特定患者亚组可以帮助针对性干预.
研究的目的:
- 调查是否通用性关节高移动性 (GJH) 是自报告COVID-19感染后无法恢复的风险因素.
- 探索具有COVID-19病史的个体中GJH和疲劳水平之间的联系.
- 确定疲劳是否调解了GJH和持续的COVID-19症状之间的关系.
主要方法:
- 采用了前性观察性研究设计.
- 从3064名通过COVID症状研究生物库报告COVID-19感染的参与者收集了数据.
- 参与者填写了GJH (5部分问卷) 和疲劳 (卡尔德疲劳量表) 的自我报告问卷.
主要成果:
- 在调整多个共同变量后,GJH与COVID-19 (OR 1.33,95% CI 1.10至1.60) 的不恢复显著相关.
- 患有GJH的个体报告了更高的疲劳水平 (B=0.95,p=0.002).
- 发现疲劳水平调解了GJH与COVID-19无法恢复之间的关联 (间接效应=0.18).
结论:
- 患有GJH的人面临~30%的不从COVID-19中恢复的可能性更高.
- 疲劳显著介导了GJH和持续的COVID-19症状之间的联系.
- 识别GJH对于识别长期COVID亚表型和个性化患者管理至关重要.
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