在七个工业制药工艺中对批量和流量化学的可持续性和技术经济评估
Mert Can Ince1, Brahim Benyahia2, Gianvito Vilé1
1Department of Chemistry, Materials, and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
ACS sustainable chemistry & engineering
|February 28, 2025
概括
与传统的批量方法相比,活性药物成分 (API) 的连续流合成提供了显著的环境效益,包括减少能源使用和浪费. 然而,对于某些溶剂密集型工艺,需要进一步优化.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 绿色化学 绿色化学
- 制药制造业 制药制造业 制药制造业
背景情况:
- 药品活性成分 (API) 的批量合成传统上受到青,但在效率,安全性和环境影响方面面临限制.
- 现有的研究往往侧重于有限的绿色指标,忽视批量与流程过程的全面技术经济和生命周期评估.
- 批量和连续流量API合成的彻底比较对于理解它们的全部环境和经济影响至关重要.
研究的目的:
- 对七种工业相关的API进行批量和连续流合成的详细比较分析.
- 评估11个类别和9个行星边界的环境影响,用于两种生产方法.
- 评估与批量和流量API制造相关的资本和运营成本.
主要方法:
- 批量和连续流程过程的比较技术经济分析 (TEA) 和生命周期评估 (LCA).
- 评估11个环境影响类别,包括能源效率,水消耗,废物产生和碳排放.
- 评估资本支出 (CAPEX) 和运营支出 (OPEX) 在七个不同的API中的两种综合方法.
主要成果:
- 连续流的工艺平均表现出优越的可持续性,在能源效率,用水和减少废物方面取得了显著的改进.
- 流合成导致碳排放大幅减少,与批量相比,能源消耗高达97%减少.
- 某些流程在运营开支和土地系统变化方面的改善较小,与使用有机溶剂相关,与批量方法相比较.
结论:
- 连续流制造为API生产提供了更绿色,更节能的替代方案.
- 需要进一步开发和优化连续流技术,以应对特定API的溶剂消耗和经济可行性的挑战.
- 该研究强调了流化学在可持续制药制造中的潜力,同时确定了技术进步的领域.
相关概念视频
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