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产前母亲的生活逆境对后代的学习和记忆产生影响:对跨代表观遗传的含义

Prince David Adeline Dorothy¹, Koilmani Emmanuvel Rajan¹

¹Behavioural Neuroscience Laboratory, Department of Animal Science, Bharathidasan University, Tiruchirappalli, India.

Frontiers in neuroscience

|February 28, 2025

概括

怀孕期间母亲的压力会影响子女跨代的记忆力. 这种表观遗传涉及H3K4甲基化的变化,影响BDNF表达和突触可塑性. 催产素治疗可以减轻这些影响.

科学领域:

神经科学是一个神经科学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
发展生物学发展生物学

背景情况:

怀孕期间母亲的压力会影响后代的神经发育和行为.
跨代表观遗传为通过母系传递这些影响提供了潜在的机制.

研究的目的:

调查产前母性压力 (PMS) 是否会诱导影响后代学习和记忆的跨代表观遗传变化.
确定催产素在减轻PMS诱导的跨代影响中的作用.

主要方法:

怀孕的老鼠 (F0) 暴露于社会压力 (PMS) 或压力加氧化素 (PMS+OXT).
后代 (F1和F2) 接受了对记忆的行为测试.
分析了表观遗传标记物 (H3K4me2/3甲基化),基因表达 (CRH,CRHR1/2,BDNF) 和皮质水平.

主要成果:

在F1和F2后代中,PMS降低了参考和工作记忆.
孕前综合征增加了CRH促进体,CRH/CRHR表达和皮质中的H3K4me2/3甲基化,同时降低了BDNF的调节.
催产素治疗逆转了这些PMS诱导的变化,改善了记忆,并使表观遗传和分子概况正常化.

结论:

产前母亲的压力会通过H3K4甲基化的表观遗传导致后代的跨代记忆缺陷.
这些表观遗传变化影响CRH和BDNF通路,影响突触可塑性.
催产素的使用可以预防或逆转这些不良的跨代效应.

关键词:

通过DNA甲基化.大脑衍生的神经营养因子皮质类皮质类固醇.表观遗传机制的表观遗传机制催产素是一种催产素.产前母亲的压力产前母亲的压力跨代遗传是一种跨代遗传.工作记忆工作记忆

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