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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

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Updated: May 1, 2026

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

器官芯片用于推进CAR治疗.

Lightson Ngashangva¹, Sunil Martin²

¹Biosensors and Biomicrofluidics Laboratory, Transdisciplinary Biology Program Rajiv Gandhi Centre for Biotechnology (RGCB) Thiruvananthapuram Kerala India.

Clinical & translational immunology

|February 28, 2025

概括

在血液癌症中,CAR治疗显示出高复发率和毒性. 器官芯片模型为动物试验提供了一个有希望的替代方案,用于评估人类相关系统中的细胞和基因疗法.

科学领域:

生物医学工程生物医学工程
免疫治疗是一种免疫疗法.
毒理学毒理学毒理学

背景情况:

化学抗原受体 (CAR) 治疗面临着高复发率 (超过60%) 和血液恶性瘤中显著的瘤外毒性挑战.
目前的模型很难复制复杂的瘤微环境 (TME) 并准确预测CAR治疗的不良影响.
监管转变鼓励用与人类相关的细胞培养系统取代动物试验.

研究的目的:

探索器官芯片 (OOC) 技术在评估CAR疗法的潜力.
解决现有模型在预测CAR疗法的疗效和毒性方面的局限性.
研究基于微流体的系统,实时进行细胞和基因疗法测试.

主要方法:

利用微流体技术创建器官芯片 (OOC) 模型.
模拟生理条件,包括微观的血液和淋巴流动动力学.
在与人类相关的背景下开发评估细胞和基因疗法的平台.

主要成果:

OOC技术有可能模仿与CAR治疗相关的复杂生物系统.
微流体平台有可能捕捉到TME的复杂的生物化学和生物物理方面.
对实时细胞和基因疗法评估的OOC应用是一个新兴的领域.

关键词:

在CAR疗法中,使用CAR疗法.微流体学在微流体学方面器官在芯片上的器官瘤免疫微环境是一个微环境.

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Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

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Last Updated: May 1, 2026

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结论:

器官芯片系统代表了细胞和基因疗法 (如CAR疗法) 临床前评估的重大进步.
这项技术为更准确地预测治疗结果和毒性提供了一条道路.
需要进一步开发才能充分实现微流体在实时细胞和基因疗法测试中的潜力.