父亲年龄与5岁以下子女死亡率和围产期结局的关联:一项使用台湾索赔数据的队列研究
Shi-Heng Wang1,2, Jian-Te Lee3, Mei-Chen Lin1
1National Center for Geriatrics and Welfare Research, National Health Research Institutes, Zhunan, Taiwan.
BMJ public health
|February 28, 2025
概括
先进的父亲年龄与更好的后代健康结果有关,包括较低的死亡率和较少的分娩并发症. 兄弟姐妹分析证实了这些好处,控制了共同的家庭因素.
科学领域:
- 生殖健康 生殖健康
- 儿科 儿科 儿科
- 流行病学 流行病学
背景情况:
- 父亲年龄对儿童健康的影响是有争议的,因为家庭的混因素.
- 这项研究调查了父亲的年龄和后代的健康状况,包括死亡率和围产期结果.
- 为了减轻混因素,使用了兄弟对比分析.
研究的目的:
- 检查晚年父亲年龄与子女五岁以下死亡率之间的关联.
- 评估父亲年龄与各种围产期结局之间的关系.
- 用兄弟姐妹比较来控制家族混因素.
主要方法:
- 全国范围的出生队列研究使用台湾国家健康保险数据 (2001-2015).
- 包括2,454,104只活生生的独生子,其中1,513,222只在兄弟姐妹对比分析中.
- 进行了后勤和条件后勤回归分析.
主要成果:
- 原始分析显示,父亲的年龄和五岁以下儿童死亡率之间存在U形关系,在混调整后,这种关系减弱了.
- 在父亲年龄>35岁时,观察到早产风险增加,出生体重低,妊娠年龄大,Apgar分数低.
- 兄弟姐妹的分析显示,年长父亲的年轻兄弟姐妹的五岁以下死亡率,低出生体重,怀孕年龄小,先天性缺陷和低Apgar分数的风险降低,但早产和怀孕年龄大的风险更高.
结论:
- 年长父亲的孩子显示,五岁以下儿童死亡率的风险降低.
- 较低的低出生体重发生率,较小的妊娠年龄,先天性缺陷和低的Apgar分数与较大的父亲年龄有关.
- 晚年父亲的年龄与早产的风险更高,在兄弟姐妹的比较中,对于妊娠年龄来说很大.
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