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在具有孤立罗宾序列的年轻成年人中描述上呼吸道空气流动力学:一项探索性调查
Maria Noel Marzano-Rodrigues1, Sergio Henrique Kiemle Trindade2, Ivy Kiemle Trindade-Suedam3
1School of Medicine, Life and Health Science Institute, Catholic University of Pelotas, Pelotas, Brazil.
Journal of oral biology and craniofacial research
|February 28, 2025
概括
患有孤立罗宾序列 (IRS) 的成年人呼吸道较小,增加阻塞性睡眠呼吸暂停风险. 这项研究使用计算流体动力学来表明,IRS患者的气道体积减少和逆发光阻塞导致气流变化,阻力增加和呼吸力度增加.
科学领域:
- 空气动力学 在空气动力学.
- 医学物理 医学物理
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 孤立罗宾序列 (IRS) 的成年人上呼吸道尺寸受损可以改变空气流动力学.
- 这种改变增加了喉崩和阻塞性睡眠呼吸暂停 (OSA) 的风险.
研究的目的:
- 为了表征上呼吸道形态生理学和空气流动力学在年轻成年人与IRS.
- 通过计算流体动力学 (CFD) 研究气道尺寸和流体流动特征之间的关系.
主要方法:
- 使用3D细分的IRS的6名年轻成年人的上呼吸道的三维 (3D) 重建.
- 为CFD模拟生成具有超过400万个四面体元素的非结构化混合网格.
- 使用可实现的k-ε模型和有限体积方法在15L/分钟的流速下解决的流量模拟.
主要成果:
- 气道体积为29.32 ± 4.65厘米3,最小的截面面积为1.00 ± 0.55厘米2.
- 在气道体积减少与气道阻力增加 (-0.899) 和压力下降 (-0.899) 之间发现了显著的相关性.
- 最小喉截面面积与空气流速大小 (-0.912) 和流动力动能产生 (-0.924) 有负相关.
结论:
- 在患有IRS的年轻人中,气道体积减少和逆光阻塞与改变的液体流量有关.
- 这些变化包括速度增加,压力下降,阻力和动动能产生.
- 这些血液动力学变化可能会增加呼吸力度,并使个人倾向于睡眠呼吸障碍.
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