创新的胃肠道药物输送系统:纳米颗粒,水凝和微
Haiming Chen1, Waliul Islam1, Jessica El Halabi1
1Division of Gastroenterology and Hepatology, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.
Frontiers in bioscience (Landmark edition)
|February 28, 2025
概括
新的药物输送系统 (DDS) 提供了更好的效能和生物可用性,克服了传统药物的局限性. 本综述强调了先进的DDS,如纳米颗粒和水凝,用于针对性胃肠道药物输送,特别是炎症性肠病 (IBD).
科学领域:
- 生物医学工程 生物医学工程
- 药品制造 药品制造 药品制造
- 药物输送系统 药物输送系统
背景情况:
- 传统的药物配方通常需要频繁的剂量,因为快速释放和短暂的消除,导致不良事件和患者不良遵守.
- 显著的研究重点是开发先进的药物输送系统 (DDS),以实现持续和有针对性的治疗输送.
- 早期的策略包括皮嵌入和聚合物封装,演变为各种治疗剂的多种DDS.
研究的目的:
- 审查用于胃肠道 (GI) 药物输送的DDS的最新进展.
- 检查专门适应独特的肠道环境的DDS设计和策略.
- 根据临床前研究,强调DDS在治疗炎症性肠病 (IBD) 中的应用.
主要方法:
- 关于DDS技术的最新文献的审查.
- 对消化道向的DDS设计原则的分析.
- 专注于纳米颗粒,水凝和微作为关键的DDS模式.
- 包括用于IBD治疗的临床前*in vivo*研究.
主要成果:
- 新兴的DDS技术增强了药物的效力,生物可用性和向性输送.
- 纳米颗粒,水凝和微型具在胃肠道药物输送方面表现有前途.
- 针对胃肠道复杂的生理条件,DDS策略正在优化.
- 临床前数据支持特定DDS在IBD管理中的有效性.
结论:
- 先进的DDS对于克服传统药物配方的局限性至关重要.
- 量身定制的DDS设计对于在肠道内有效的药物输送至关重要.
- 进一步的研究和临床前验证对于将这些DDS技术转化为临床实践至关重要,特别是在IBD治疗中.
相关概念视频
01:18Drug Delivery: Enteral Route
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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01:16Drug Delivery: Overview
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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01:22Drug Delivery: Miscellaneous Routes
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01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
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01:09Methods for Studying Drug Absorption: In situ
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In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
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01:18Routes of Drug Administration: Enteral
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Medications can be administered through the enteral route using liquids, capsules, or tablets.
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