Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

147
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
147
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

92
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
92

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Chaihu Shugan San alleviates depression-like behavior in rats exposed to chronic unpredictable mild stress by targeting α2δ-1-NR1 complex in hypothalamus.

The Journal of pharmacy and pharmacology·2026
Same author

Unrevealing the role of hypothalamic corticotropin-releasing hormone neurons in blood pressure regulation in hypertension.

Cardiovascular research·2025
Same author

Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension.

Cardiovascular research·2023
Same author

Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala.

Journal of neurochemistry·2022
Same author

Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension.

Cardiovascular research·2021
Same author

Paraventricular hypothalamus mediates diurnal rhythm of metabolism.

Nature communications·2020

相关实验视频

Updated: May 24, 2025

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
10:10

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

12.6K

微质介导的突触功能障碍有助于化疗相关的认知障碍.

Jingxiong Wang1, Hua Zhang1, Marc Augenreich2

  • 1Department of Medicine, University of Missouri-Columbia School of Medicine, Columbia, Missouri, USA.

Journal of neurochemistry
|February 28, 2025
PubMed
概括

化疗通过影响微质细胞和突触可塑性而损害认知能力. 米诺环素治疗逆转了这些影响,这表明微质功能障碍驱动了化疗相关的认知障碍 (CRCI).

关键词:
化疗 化疗是一种化学疗法.认知缺陷 认知缺陷长期的增强潜力.微质细胞中的微质细胞突触传输是一种突触传输.

更多相关视频

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

18.1K
A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.1K

相关实验视频

Last Updated: May 24, 2025

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
10:10

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

12.6K
Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

18.1K
A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.1K

科学领域:

  • 神经科学是一个神经科学.
  • 在瘤学瘤学.
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 化疗相关的认知障碍 (CRCI) 是癌症幸存者面临的重大挑战.
  • CRCI的潜在机制尚不清楚,这限制了有效的治疗开发.
  • 微质和突触可塑性是CRCI病变发生的潜在关键因素.

研究的目的:

  • 调查微质介导的突触可塑性缺陷是否有助于CRCI.
  • 确定5-甲和leucovorin (5-Fu/LV) 对小鼠认知功能,微质活动和突触可塑性的影响.
  • 评估米诺环林在缓解5-Fu/LV诱导的认知缺陷方面的治疗潜力.

主要方法:

  • 成年雄性小鼠接受了5-Fu/LV化疗或载体治疗.
  • 用新型对象识别 (NOR) 测试来评估认知功能.
  • 微质形态和活性通过Iba1和CD68染色来评估.
  • 测量了海马长期强化 (LTP) 和N-甲基-D-酸受体刺激后突触电流 (NMDAR-EPSCs).
  • 小鼠同时接受微质抑制剂米诺环素的治疗.

主要成果:

  • 在NOR测试中,5-Fu/LV治疗诱导认知缺陷.
  • 化疗改变了微质形态,增加了CD68阳性微质,减少了细胞分裂.
  • 5-Fu/LV降低了海马中的LTP和NMDAR-EPSCs.
  • 米诺环素治疗恢复了认知功能,使微质变化正常化,并逆转了突触可塑性缺陷.

结论:

  • 微质功能障碍,其特征是形态变化和减少的细胞化,与化疗诱导的认知障碍有关.
  • 突触可塑性缺陷,特别是减少的LTP和NMDAR-EPSC,有助于CRCI.
  • 用米诺环林等药物向微质活动可能为CRCI提供治疗策略.