急性胰腺炎的长期死亡率 - 一项基于人口的队列研究
Daniel Selin1,2, John Maret-Ouda2,3, Viktor Oskarsson4,5
1Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
United European gastroenterology journal
|February 28, 2025
概括
急性胰腺炎显著增加了长期死亡风险,即使考虑到其他健康问题和复发性疾病. 这一发现凸显了对这种胰腺炎的更好理解和预防策略的关键需求.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 急性胰腺炎是一种严重的胰腺炎症,在全球范围内发生率越来越高.
- 以前的研究表明,急性胰腺炎与长期死亡率增加之间存在联系.
- 慢性胰腺炎或癌症等并发症对这种关联的影响需要进一步调查.
研究的目的:
- 确定急性胰腺炎与长期全因死亡率之间的关联.
- 与一般人口队列相比,分析急性胰腺炎幸存者的死亡风险.
主要方法:
- 利用瑞典胰腺炎队列 (SwePan) 数据库,包括首次急性胰腺炎病例 (1990-2019) 和匹配的对照.
- 采用多变量有条件的Cox比例危险模型进行比较性死亡率分析.
- 对89465名急性胰腺炎患者和890,837名对照患者进行了超过1000万人年的随访.
主要成果:
- 患有急性胰腺炎的个体经历了明显更高的全因死亡率 (37.7%) 与对照 (29.8%).
- 在整个随访期间,死亡率的增加一直持续,特别是在严重的非胆结石病例中.
- 即使在调整并发病症和对复发性或慢性胰腺炎进行审查后,这种关联仍然很重要.
结论:
- 急性胰腺炎独立地与长期死亡率的增加有关,无论伴随疾病或进展为慢性胰腺炎.
- 需要进一步的研究,以确定特定的死亡原因和长期发病率.
- 制定量身定制的后续策略对于预防急性胰腺炎患者的死亡率至关重要.
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