相关实验视频

Updated: May 24, 2025

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

功能性PEGylated Adipate共聚物的酶合成

Eleni Axioti¹, Emily G Dixon¹, Thomas Jepras¹

¹School of Chemistry, University Park, Nottingham, NG7 2RD, United Kingdom.

|February 28, 2025

概括

使用聚乙烯糖醇 (PEG) 和疏水性二醇的新型聚合物纳米粒子 (NP) 为难溶活性药物成分 (API) 提供了改善的药物输送. 这些新型的PEGylated聚合物显示出有前途的稳定性和高封装效率.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
纳米技术纳米技术

背景情况:

许多新的活性药物成分 (API) 具有较差的水溶性,阻碍了它们的治疗应用.
聚合物纳米颗粒 (NP) 广泛用于封装疏水性API,聚乙烯糖醇 (PEG) 是由于其生物相容性和延长药物停留时间的能力而成为常见的选择.
然而,PEGylation面临着挑战,包括免疫性,有限的生物降解性和有限的化学功能.

研究的目的:

使用酶合成路径开发新的PEGylated聚合物.
研究将疏水性二醇纳入PEGylated骨干对NP形成,稳定性和药物封装的影响.
确定最佳配方,以增强疏水性API的药物输送.

主要方法:

新型PEGylated聚合物的酶合成.
在50:50的比例下将疏水性二醇 (1,6-hexanediol和2-hydroxyethyl disulfide) 纳入PEGylated骨干中.
纳米粒子 (NP) 形成,稳定性,生物相容性和封装效率的表征.

主要成果:

两个配方,PEGA-Hex 50% (PEG和1,6-hexanediol) 和PEGA-SS 50% (PEG和2-乙烯二硫化物),成为最有前途的候选人.
这些选定的配方显示了足够的NP稳定性和生物相容性.
与其他变体相比,PEGA-Hex 50%和PEGA-SS 50%的封装效率更高.

结论:

通过酶途径合成的新型PEGylated聚合物提供了一种可行的战略,用于输送疏水性API.
加入特定的疏水性二醇显著提高了NP稳定性和药物封装效率.
百分之五十的PEGA-Hex和百分之五十的PEGA-SS代表了开发先进的药物输送系统的有希望的候选人,以挑战API.

关键词:

药物输送是药物输送的过程.酶性聚合酶化是一种酶性聚合.纳米颗粒纳米颗粒这就是PEG PEG PEG.多重凝结方式的多重凝结.

更多相关视频

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

Particles without a Box: Brush-first Synthesis of Photodegradable PEG Star Polymers under Ambient Conditions

Particles without a Box: Brush-first Synthesis of Photodegradable PEG Star Polymers under Ambient Conditions

Published on: October 10, 2013

相关概念视频

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...

ATP and Macromolecule Synthesis

ATP and Macromolecule Synthesis

Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...

Step-Growth Polymerization: Overview

Step-Growth Polymerization: Overview

Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...