在儿科阻塞性睡眠呼吸暂停的高度炎症状态的危险因素
Yanyu He1, Xueyun Xu1, Meng Lv1
1Department of Respiratory, Children's Hospital Affiliated to Soochow University, No. 303, Jingde Road, Suzhou, Jiangsu Province, China.
Sleep & breathing = Schlaf & Atmung
|February 28, 2025
概括
儿科阻塞性睡眠呼吸暂停 (OSA) 的高炎症状态与更高的BMI和呼吸暂停持续时间有关. 高灵敏度C反应蛋白 (hsCRP) 可以识别患有这种高炎症状态的儿童.
科学领域:
- 儿科睡眠医学 儿科睡眠医学
- 心血管健康 心血管健康
- 炎症研究 炎症研究
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 可能导致慢性系统性炎症,导致并发症.
- 在儿科OSA中识别高炎症状态 (HIS) 对诊断和管理至关重要.
- 这项研究评估了影响hsCRP的因素和儿童OSA中HIS的风险.
研究的目的:
- 评估影响高灵敏性C反应蛋白 (hsCRP) 水平的因素.
- 在小儿OSA患者中识别与高炎症状态 (HIS) 相关的危险因素.
主要方法:
- 包括1,171名患有打症状的儿童 (3-15岁),接受了多睡眠图 (PSG).
- 通过问卷,体检 (BMI,桃体缩),鼻X射线和血液检查收集的数据.
- 使用ROC曲线来确定HSCRP的HIS和低炎症状态的值.
主要成果:
- 562名儿童被诊断患有OSA;299人患有HIS,872人患有低炎症状态.
- 患有HIS的小儿OSA患者的hsCRP水平,BMI和超重/肥胖率显著上升.
- 后勤回归显示,HIS与BMI和平均阻塞性呼吸暂停时间正相关,与最小SPO2负相关.
结论:
- 在患有HIS的儿科OSA患者中,HsCRP水平升高.
- 体重指数 (BMI),平均阻塞性呼吸暂停时间和最小的SPO2是导致HIS的独立因素.
- hsCRP作为一种有效的血液生物标志物,用于识别小儿OSA中的HIS.
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