相关实验视频

Updated: May 8, 2025

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

近红外光探针的最新发展,从NIR-I到NIR-II用于生物成像

Yuzuka Kuronuma¹, Ryuji Watanabe¹, Yuki Hiruta²

¹Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa, 223-8522, Japan.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

|February 28, 2025

概括

本综述涵盖了近红外 (NIR) 光成像探测器的进展,从NIR-I到NIR-II区域. 这些探测器,特别是以素和胺为基础的探测器,增强了高分辨率和低背景的深层组织生物成像.

科学领域:

生物医学成像技术生物医学成像技术
光学光谱学是指光学光谱学.
分子探头分子探头

背景情况:

近红外I (NIR-I) 光成像使深层组织可视化,但面临透深度限制.
近红外II (NIR-II) 成像 (1000-1700nm) 通过尽量减少光散射和组织自光来提供更高的分辨率和更低的背景.
尼尔射线光探测器对于实时,时空探索生理事件至关重要.

研究的目的:

审查最近在小分子近红外光染料和探针的进展.
为突出探测跨越NIR-I和NIR-II光谱区域的进展.
展示这些探测器在各种生物成像环境中的应用.

主要方法:

专注于小分子光染料,特别是那些使用素和胺支架的光染料.
分析探头设计策略,以提高光学性能.
最近在生物和生物医学成像中的应用的汇编.

主要成果:

开发具有改进性能特性的新型NIR光探头.
证明了增强的深层组织透和减少信号干扰.
在各种生物成像研究中成功应用NIR探针.

结论:

小分子NIR光探针,特别是氨酸和胺衍生物,正在快速推进生物成像能力.
尼尔-I和尼尔-II探针为高分辨率,深层组织成像提供了强大的工具.
这些探头对于实时生理事件监测和疾病诊断至关重要.

关键词:

生物成像是一种生物成像.氨酸是一种氨酸.光探测器探测器可以发光.在NIR-II中,我们可以看到NIR-II.接近红外的近红外.罗达胺是一种胺.

更多相关视频

Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging

Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging

Published on: January 5, 2015

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Published on: September 19, 2014

相关概念视频

Super-resolution Fluorescence Microscopy

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...

Labeling DNA Probes

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...