结构方程建模用于探索儿童癌症幸存者慢性疲劳的假定因果因素:DCCSS LATER研究
Adriaan Penson1, Ioan Gabriel Bucur2, Iris Walraven3
1Center of Expertise for Cancer Survivorship, Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands. adriaan.penson@radboudumc.nl.
Journal of cancer survivorship : research and practice
|February 28, 2025
概括
儿童癌症幸存者经历了与性有关的慢性疲劳 (CF),无助感,身体活动低,疼痛,BMI和睡眠问题. 肌痛性肌痛还与抑郁症有双向关系,影响日常生活.
科学领域:
- 在瘤学瘤学.
- 心理学 心理学 心理学
- 公共卫生 公共卫生
背景情况:
- 儿童癌症幸存者 (CCS) 经常经历长期的健康问题.
- 慢性疲劳 (CF) 是一种普遍且使人虚弱的疾病,影响CCS的生活质量.
- 了解CCS中CF的复杂原因对于开发有效干预措施至关重要.
研究的目的:
- 在儿童癌症幸存者 (CCS) 中调查各种因素和慢性疲劳 (CF) 之间的因果关系.
- 利用结构方程建模 (SEM) 和因果发现方法来绘制这一群体中CF的病因.
主要方法:
- 采用结构方程建模 (SEM) 和因果发现方法来分析相互关系.
- 使用1000个样本的引导方法来评估已识别的因果关系的可靠性和稳定性 (可靠性>50%).
- 分析了1927年的CCS数据,其中23.6%报告CF.
主要成果:
- 确定了性别对CF的假定因果作用 (81%的信心).
- 在CF和无助 (82%),体力活动 (78%),疼痛 (78%),BMI (51%) 和睡眠问题 (51%) 之间确立了因果关系.
- 揭示了CF和抑郁症 (68%的信心) 之间的双向关系,表明相互影响或共同的潜在因素.
结论:
- 这项研究阐明了儿童癌症幸存者的慢性疲劳的多方面的起源.
- 研究结果为制定针对CCS中CF的有针对性的预防和干预策略提供了指导.
- 结果强调了CF的重大后果及其对幸存者的日常生活的影响.
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