在小儿科F-FDG扫描中使用30厘米轴视野PET/CTCT的低剂量方案
Ha Wu1,2,3,4,5, Guobing Liu1,2,3,4, Xiemei Ruan5
1Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 in Fenglin Road, Shanghai, 200032, China.
Annals of nuclear medicine
|February 28, 2025
概括
对于儿科患者来说,低剂量2.5 MBq/kg 18F-FDG PET/CT 协议与3.0分/床的获取是可行的. 这种方法保持了诊断图像质量和30厘米SAFOV PET/CT成像中病变检测能力.
科学领域:
- 核医学是一种核医学.
- 放射性药房 是一个放射性药房.
- 儿科成像学 儿科成像学
背景情况:
- 标准的18F-FDG PET/CT协议在儿科患者中涉及更高的辐射剂量.
- 优化成像协议至关重要,以最大限度地减少儿童的辐射暴露.
研究的目的:
- 评估使用30厘米标准轴视野 (SAFOV) 的小儿病人的降低剂量18F-FDG PET/CT协议的可行性.
- 评估图像质量,病变检测能力和辐射剂量减少.
- 为了比较全剂量和低剂量方案之间的结果.
主要方法:
- 对112名儿科患者进行了全剂量 (3.7 MBq/kg) 18F-FDG PET/CT的回顾性分析.
- 55名儿科患者的前性分析,低剂量 (2.5 MBq/kg) 18F-FDG PET/CT.
- 图像质量通过利克特尺度和信号噪声比 (SNR) 评估;通过检测率和目标与肝脏比 (TLR) 检测损伤的检测能力.
主要成果:
- 使用2.0和3.0分钟/床的全剂量成像 (G2.0,G3.0) 实现了100%的病变检测率和图像得分≥3.3.
- 低剂量成像以3.0分钟/病床获取 (G3.0') 显示98.2%的病例的图像得分≥3和100%的病变检测.
- SNR和TLR显示了与年龄相关的差异,但低剂量SNR与全剂量SNR在不同年龄组中相当.
结论:
- 对于儿科患者来说,低剂量 (2.5 MBq/kg) 18F-FDG PET/CT 协议与3.0分钟/床的获取是可行的.
- 该协议提供了诊断图像质量和病变检测能力,与全剂量成像相提并论.
- 随着年龄的变化,SNR和TLR的变化需要进一步调查.
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