心血管疾病风险预测和亚洲印第安人中患有1型和2型糖尿病的亚洲印第安人
Sengottuvelu Aswath Krishna1, Ulagamathesan Venkatesan2, Anandakumar Amutha2
1Stanley Medical College, Chennai, Tamilnadu, India.
年轻发病的糖尿病患者,特别是2型糖尿病 (T2D) 患者,10年内面临心血管疾病 (CVD) 高风险. QRISK3和弗雷明汉风险评分都有效地预测了亚洲印第安人的心血管疾病风险.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 糖尿病研究 糖尿病研究
背景情况:
- 心血管疾病 (CVD) 是糖尿病患者的主要并发症.
- 年轻发病的糖尿病,定义为10-30岁之间发病,对心血管疾病风险评估提出了独特的挑战.
- 亚洲印第安人群体对糖尿病和心血管疾病有不同的风险因素概况.
研究的目的:
- 根据心血管疾病 (CVD) 风险,对亚洲印第安人患有年轻发病的1型糖尿病 (T1D) 和2型糖尿病 (T2D) 进行分析.
- 在这个人群中评估QRISK3和Framingham风险评分 (FRS) 的预测性能.
- 为了比较亚洲印第安人的年轻发病T1D和T2D之间的心血管疾病风险.
主要方法:
- 从糖尿病电子医疗记录中对18837名年轻T1D或T2D患者进行了回顾性分析.
- 利用QRISK3和FRS估计10年心血管疾病风险,将风险分类为高 (≥10.0%) 或低 (<10.0%).
- 计算了5371人的QRISK3和7444人的FRS,排除了以前患有心血管疾病的人.
主要成果:
- 17.3%的T1D和31.9%的T2D个体具有高的QRISK3分数.
- 19.0%的T1D和37.2%的T2D个体具有高的FRS分数.
- 患有T2D的个体的心血管疾病风险明显高于T1D (p < 0.001);风险随着年龄的增长而增加,男性的风险更高. 无论是QRISK3 (0.788) 和FRS (0.746) 都显示出良好的预测能力 (ROC-AUC).
结论:
- QRISK3和FRS是预测亚裔印度裔年轻糖尿病患者10年心血管疾病风险的有效工具.
- 年轻发病的T2D与年轻发病的T1D相比,携带更高的心血管疾病风险.
- 定期监测心血管疾病风险,改变生活方式和医疗干预措施对于管理年轻糖尿病患者至关重要.
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