儿童疾病中的循环生长差异化因子15 (GDF15):系统性审查
David W Kronenberger1, Teresa A Zimmers2, Rick K Ralston3
1Indiana University School of Medicine, Indianapolis, Indiana, USA.
Journal of cachexia, sarcopenia and muscle
|February 28, 2025
概括
增长差异化因子15 (GDF15) 水平在儿科疾病中有所不同,心脏骤停和线粒体状况中发现的最高水平. 标准化GDF15测量对于其在儿童的临床使用至关重要.
科学领域:
- 儿科医学 儿科医学
- 生物化学 生化学
- 炎症研究 炎症研究
背景情况:
- 增长分化因子15 (GDF15) 是一种炎症标志物,在新陈代谢中起作用.
- 现有的关于儿童群体GDF15的文献是有限的.
- GDF15对成人疾病如癌症缓解症和怀孕有兴趣.
研究的目的:
- 审查和总结关于GDF15的现有儿科研究.
- 描述GDF15在儿童中被研究的疾病背景.
- 确定研究缺口,并建议GDF15在儿科的未来方向.
主要方法:
- 按照PRISMA-ScR指南进行系统审查.
- 搜索了奥维德·梅德林 (Ovid MEDLINE),埃姆巴斯 (Embase),科克莱恩图书馆 (Cochrane Library) 和斯科普斯 (Scopus) 这些网站.
- 包括测量从出生到18岁的个体GDF15的研究.
主要成果:
- 分析了62项跨越各种儿科疾病 (心脏,内分泌,瘤等) 的研究. ) 的情况.
- 在心脏骤停和线粒体疾病中发现了最高的GDF15中位数.
- 在治疗Kawasaki病和PCOS等疾病时,GDF15水平可以正常化.
结论:
- GDF15已在各种儿科疾病中进行研究.
- 方法的变化阻碍了GDF15研究的直接比较.
- 需要标准化GDF15测量以澄清其在儿童中的诊断效用和治疗潜力.
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