在接受不同治疗的类风湿性疾病患者中结核感染
Tianhui Liu1, Hongxuan Yan1, Mengqiu Gao2
1Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Postal No 9, Beiguan Street, Tongzhou District, Beijing 101149, People's Republic of China.
Journal of infection and public health
|February 28, 2025
概括
接受生物疾病修饰性抗风湿药物 (bDMARD) 的类风湿病患者腔较少,但肺外结核 (EPTB) 较多. 结核病在开始bDMARDs后的六个月内发展,根据治疗表现出不同的临床特征.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 风湿性疾病需要免疫抑制疗法,增加对结核病 (TB) 等感染的易感性.
- 了解不同治疗的风湿性疾病患者的结核病表现对于及时诊断和管理至关重要.
研究的目的:
- 为了研究结核病 (TB) 的临床特征,在患有风湿性疾病的患者中.
- 将接受不同治疗方案的患者之间的结核病表现和结果进行比较,包括生物疾病修饰性抗风湿药物 (bDMARDs),常规合成疾病修饰性抗风湿药物 (csDMARDs) 和没有免疫疗法.
主要方法:
- 从2009年1月至2022年10月期间被诊断患有结核病的风湿病患者的临床数据的回顾性分析.
- 根据药物治疗,患者被分为三个组:bDMARDs,无免疫疗法和csDMARDs.
主要成果:
- 接受bDMARD治疗的患者出现的发病率较低,但肺外结核 (EPTB) 的可能性更高.
- 在接受bDMARDs的患者中,很大一部分患者在治疗开始后的六个月内发展为结核病.
- 结核病感染的临床特征在不同治疗组之间显著不同.
结论:
- 治疗方案显著影响结核病的临床表现和特征,在患有类风湿性疾病的患者.
- 这些发现强调了考虑特定结核病表现 (例如,EPTB) 和bDMARDs患者发病时间的重要性.
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