形态学,物理化学性质和持续释放特征的短氨/WPI修改了DBD血-常规纳米复合物的DBD
Xiaojing Li1, Ting Xu1, Gongjian Fan1
1College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing, Jiangsu 210037, China; Co-Innovation Center for the Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu 210037, China.
Food chemistry
|February 28, 2025
概括
乳清蛋白分离物 (WPI) 被血修饰并与短粉素 (SA) 结合,形成了一个三元复合体,用于持续释放 rutin. 这种新型纳米载体显著改善了 rutin.
科学领域:
- 食品科学 食品科学 食品科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 乳清蛋白分离物 (WPI) 是一种有价值的蛋白质来源,具有控制释放应用的潜力.
- 介电屏障放电 (DBD) 的等离子体修饰增强了WPI的特性.
- 素是一种黄类化合物,具有健康益处,但需要改进的输送系统.
研究的目的:
- 使用DBD血改性WPI (DWPI) 和短氨 (SA) 开发三元复合物,以持续释放鲁丁.
- 在不同的DWPI/SA比率下研究DWPI/SA-rutin三元复合物的物理化学特性.
- 评估三元复合结构对鲁的激素清除活动和释放概况的影响.
主要方法:
- 制造具有不同DWPI/SA比率的DWPI/SA-常规三元复合体.
- 纳米粒子形态,粒子大小和相互作用力 (键,静电,疏水) 的表征.
- 在模拟口腔和胃消化后,评估鲁丁的激素清除活性和体外累积释放率.
主要成果:
- 三级复杂纳米粒子呈现出球形状的趋势,并且具有更高SA含量的粒子大小增加.
- 在1:1的DWPI/SA比率下,变化 (ΔH) 显著增加649.71%,表明强烈的相互作用.
- 在消化后,鲁的激素清除活性显著增强,累积释放量减少到27.11%,在1:4的DWPI/SA比率下.
结论:
- 该DWPI/SA-rutin三元复合物有效地封装了 rutin,增强了其稳定性和生物可用性.
- DWPI与SA的比率极大地影响了复合物的物理化学特性和持续释放性能.
- 这项研究提出了一种新且有效的方法,用于创建粉/蛋白质纳米载体,以改善 rutin 传递.
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