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Updated: Jun 16, 2025

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
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一种progranulin变体导致儿童间歇性肺病,对抗TNF-α生物治疗有反应

John C Kennedy1, Sara O Vargas2, Martha P Fishman3

  • 1Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Med (New York, N.Y.)
|February 28, 2025
PubMed
概括

一个罕见的基因变异在progranulin (GRN) 基因导致严重的肺部和肝脏疾病在一个孩子. 向的抗瘤坏死因子α (TNF-α) 治疗导致显著的恢复,展示了用于罕见儿科疾病的精密药物.

关键词:
这就是TNF-α.翻译给患者使用.儿童间歇性肺病 儿童间歇性肺病纤维化肺部疾病 纤维化肺部疾病巨细胞是一个巨细胞.精准医学是一门精准医学.益格拉努林是一种前列腺素.这是一种罕见的肺部疾病.空间转录学 空间转录学

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