在外周动脉疾病的家庭运动和患者报告的结果:LITE随机临床试验
Mary O Whipple1, Shujun Xu2, Dongxue Zhang2
1School of Nursing, University of Minnesota, Minneapolis, Minnesota.
The American journal of cardiology
|February 28, 2025
概括
与低强度或不运动相比,高强度的行走运动显著改善了外周动脉疾病 (PAD) 患者的行走能力和患者报告的结果. 高强度运动增加了PAD症状显著改善的可能性.
科学领域:
- 心血管医学 心血管医学
- 运动生理学 运动生理学
- 康复科学 康复科学 康复科学
背景情况:
- 周围动脉疾病 (PAD) 显著影响患者的流动性和生活质量.
- 目前针对PAD的运动指南通常建议低强度或舒适的步行步行.
- 为了在PAD中获得有意义的临床益处,最佳的运动强度仍在研究中.
研究的目的:
- 为了比较高强度 (诱导缺血症) 与低强度 (舒适的步伐) 步行运动对患者报告的结果 (PROM) 和PAD患者客观步行能力的影响.
- 评估关键结果措施的临床重要差异最小值 (MCID) 的实现.
主要方法:
- 一项随机对照试验,涉及240名PAD参与者,比较了12个月的高强度行走,低强度行走和一个不运动的对照组.
- 使用6分钟步行测试 (6MWT) 评估了目标步行能力.
- 患者报告的结果包括走路障碍问卷 (WIQ) 距离和速度得分.
主要成果:
- 与低强度运动和对照组相比,高强度运动显著改善了6MWT距离.
- 与其他两组相比,高强度运动显著增加了6MWT实现MCID的几率.
- 与对照组相比,高强度运动也显著增加了获得WIQ距离和速度得分的MCID的几率.
结论:
- 与低强度运动和非运动对照相比,高强度步行运动在PAD患者的客观步行能力方面具有更好的益处.
- 虽然高强度运动与对照组相比改善了PROM,但对于这些特定措施来说,它没有显示出相对于低强度运动的显著优势.
- 这些发现表明,高强度运动可能是一种有价值的治疗策略,用于改善PAD患者的功能能力.
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