一种可注射的多种模式的硫化碳甲基纤维素凝,用于治疗晚期胃癌
Tao Wu1, Jingqiu Zhou1, Wanli He2
1College of Medicine and Biological Information Engineering, Northeastern University; Shenyang 110169, China; Department of Biomedical Engineering, Shenyang University of Technology, Shenyang 110870, China; Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang 110840, China.
International journal of biological macromolecules
|February 28, 2025
概括
一种新的水凝通过克服化疗耐药性来对抗胃癌 (GC). 这种对GSH敏感的材料通过联合疗法增强了治疗效果,在临床前模型中显示出显著的瘤减少.
科学领域:
- 生物材料科学 生物材料科学
- 癌症治疗 癌症治疗
- 药物运输 药物运输 药物运输
背景情况:
- 化疗是可切除胃癌 (GC) 的标准,但由于高瘤谷氨 (GSH) 水平而受到限制.
- 在GC细胞中增加的GSH降低了化疗疗效,需要新的治疗策略.
研究的目的:
- 开发一种GSH敏感的可注射水凝,用于高级GC多式疗法.
- 通过结合化学动力学疗法,饥饿疗法和化疗来增强抗瘤活性.
主要方法:
- 合成了二氧化碳甲基纤维素 (T-CMC),并使用XPS,FTIR和13C NMR进行了表征.
- 开发了一种T-CMC@Fe3+(5-FU + GOx) 水凝,其中包含铁离子,葡萄糖氧化酶和5-甲.
- 在异种移植模型中评估了GSH反应性降解,生物相容性,体外抗瘤疗效和体内抗瘤效应.
主要成果:
- 水凝显示了GSH反应性降解和良好的生物相容性.
- 与单独使用化疗相比,体外研究显示GC细胞活力显著降低 (12.28 ± 2.88%).
- 在体内研究中,在14天内,瘤体积显著减少 (8.12 ± 4.89 mm3).
结论:
- 这种T-CMC@Fe3+(5-FU + GOx) 水凝有效地增强了晚期GC的抗瘤活性.
- 这种多模式治疗方法为改善GC治疗结果提供了一个有希望的策略.
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