在产前维生素和叶酸补充剂中的重金属和酸盐污染
Hannah Gardener1, Jaclyn Bowen2, Sean P Callan3
1University of Miami, Miller School of Medicine, Department of Neurology, Miami, Florida, USA.
Environmental research
|February 28, 2025
概括
许多产前维生素含有令人担忧的和水平. 需要制定法规,以确保这些必需的补充剂对孕妇的安全性.
科学领域:
- 环境健康 环境健康
- 营养科学 营养科学
- 分析化学 分析化学
背景情况:
- 产前维生素对于母亲和胎儿的健康至关重要.
- 补充剂与重金属和甲酸盐的污染构成重大风险.
- 现有的法规可能无法充分解决产前补充剂中的污染物水平.
研究的目的:
- 量化产前维生素和叶酸/叶酸补充剂中的,和酸污染.
- 为了比较不同类型的产品 (商业,处方,叶酸/叶酸) 的污染水平.
- 识别与较高污染水平相关的产品特征.
主要方法:
- 对156种商业产前维生素,19种叶酸/叶酸补充剂和9种处方产前补充剂的分析.
- 感应合等离子体质谱仪用于和的量化.
- 液体色谱-双重质谱测量用于甲酸盐量化.
- 污染物水平与加利福尼亚州65号提案的值的比较.
主要成果:
- 在83%的商业产前维生素中,超过了量化的极限 (LOQ),其中15%超过了0.5μg/份的安全门.
- 在73%的商业产前维生素中,超过了LOQ.
- 甲酸盐 (DEHP,DBP) 分别在25%和13%的样本中检测到.
- 处方产前维生素也显示出大量的和污染.
- 叶酸/叶酸补充剂表现出较低的重金属和酸盐污染.
结论:
- 许多产前维生素中存在大量的,和酸盐污染.
- 较高剂量的和铁,以及特定的形式 (囊,囊,片),与增加的重金属污染有关.
- 迫切需要明确,可执行的规定来测试和限制产前补充剂中的污染物.
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