皮肤胺合成在儿科埃索诺菲尔性食道炎中受到失调
Elena Goleva1, Donald Y Leung1, Kira Chaiboonma2
1Department of Pediatrics, National Jewish Health, Denver, Colo.
The Journal of allergy and clinical immunology
|February 28, 2025
概括
患有乙性食道炎 (EoE) 的儿童在皮肤中表现出减少的胺,这表明潜在的皮肤屏障生物标志物对EoE风险. 这表明皮肤和食道之间存在统一的上皮屏障.
科学领域:
- 皮肤病学和胃肠病学
- 生物化学 生化学
- 免疫学 免疫学 免疫学
背景情况:
- 性食道炎 (EoE) 和亚托皮性皮炎 (AD) 涉及上皮屏障功能障碍.
- 皮肤和食道之间的倾向因素和共同点尚未得到充分理解.
- 目前,没有可靠的替代标志物用于评估EoE风险.
研究的目的:
- 研究患有EoE的儿童同时出现的皮肤和食道功能障碍.
- 为了评估被诊断患有EoE的儿童皮肤中的陶化物 (CER) 水平.
- 探索潜在的EoE基于皮肤的生物标志物.
主要方法:
- 从EoE儿童 (n=21) 和对照儿童 (n=17) 的前臂收集了皮肤带 (STS).
- 试验对象是非皮炎 (非AD) 和非EoE对照.
- 分析了皮肤脂质组成,特别是胺,使用液体染色学双重质谱法.
主要成果:
- 与对照人群相比,患有EoE的儿童在皮肤中表现出明显较低的特定陶胺 (CER) 水平.
- 减少的CER包括那些含有22碳长链斯芬戈辛或植物素和含有α-基脂肪酸的斯芬戈辛CER.
- 含有超长链脂肪酸的CER在患有EoE的儿童的皮肤中显著减少.
结论:
- 在患有EoE的儿童的皮肤中存在长链胺的可证明差异,即使没有AD.
- 皮肤屏障胺水平可能作为EoE的潜在生物标志物.
- 这些研究结果支持了"一带一路"的概念.
- 统一的上皮细胞屏障
- 它连接了皮肤和食道.
相关概念视频
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Esophageal Strictures-I: Introduction
54
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
54
Assembly of the Lipid Bilayer in the ER
3.1K
Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
3.1K
Barrett Esophagus-II: Clinical Manifestations and Management
93
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
93
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.0K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.0K


