相关实验视频
Updated: May 24, 2025

05:25
A Wind Tunnel for Odor Mediated Insect Behavioural Assays
Published on: November 30, 2018
11.6K
前列腺素E2通过嗅觉通路激活脑下垂体轴在雄性Bostrychus sinensis中
Ke Wei1, Ke Jiang1, Shi Xi Chen2
1State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, Fujian 361102, China.
The Journal of steroid biochemistry and molecular biology
|February 28, 2025
概括
前列腺素E2 (PGE2),在雄性 Bostrychus sinensis 中的关键性爱激素,激活生殖通路. 这项研究揭示了PGE2如何触发大脑-垂体轴和生殖行为.
科学领域:
- 神经内分泌学神经内分泌学
- 生殖生物学 生殖生物学
- 化学生态化学生态学
背景情况:
- 前列腺素E2 (PGE2) 是一个已知的男性 Bostrychus sinensis 的性激素.
- 导致PGE2生殖作用的分子和神经机制尚未完全理解.
研究的目的:
- 调查前列腺素E2 (PGE2) 在调节雄性Bostrychus sinensis的繁殖中的分子和神经机制.
- 为了识别PGE2暴露激活的基因和通路.
主要方法:
- 在PGE2暴露后,雄性B. sinensis大脑的转录组测序 (RNA-seq).
- 反转录聚合酶链反应 (RT-PCR) 用于基因表达的验证.
- BsKiss2-12的合成和使用.
- c-fos诱导和DiI追踪用于神经通路分析.
主要成果:
- PGE2显著上调了参与脑下垂体轴激活的基因,包括大脑中的gnrh1和kiss2,以及脑下垂体中的lhβ.
- BsKiss2-12的使用增加了gnrh1,kiss1ra和lhβmRNA水平.
- PGE2激活了嗅觉感官神经元,信号传递到嗅球和生殖中心.
结论:
- 在雄性B. sinensis中,PGE2通过分子和神经通路调节生殖轴.
- 这项研究阐明了前列腺素E2和kiss2在鱼类生殖调节中的作用.
- 研究结果提供了关于费洛蒙介导的生殖行为的神经内分泌控制的见解.
相关概念视频
Physiology of Smell and Olfactory Pathway
7.8K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
7.8K
Parasympathetic Signaling
1.6K
Parasympathetic signaling plays a crucial role in regulating various physiological processes. It involves the release of acetylcholine (ACh) by parasympathetic neurons, which can have localized and short-lived effects. The majority of ACh released is rapidly inactivated at the synapse by the enzyme acetylcholinesterase (AChE), which hydrolyzes Ach into choline and acetate. Additionally, the tissue cholinesterase deactivates any ACh diffusing into the surrounding tissues.
The effects of...
The effects of...
1.6K
Regulation of Hormone Secretion
3.1K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
Humoral...
3.1K
Sympathetic Signaling
828
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
828

