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分子流行病学和抗生素耐药性概况的金黄色葡萄球菌从驼乳腺炎分离
Hamza Rasheed1, Muhammad Ijaz1, Arslan Ahmed1
1Department of Veterinary Medicine, University of Veterinary and Animal Sciences, 54000, Lahore, Pakistan.
Microbial pathogenesis
|February 28, 2025
概括
抗生素耐药的金黄色葡萄球菌,包括MRSA,在驼驼乳腺炎中很普遍. 糟糕的农场卫生和动物健康是关键的风险因素,需要改进管理和有针对性的治疗来打击耐药性.
科学领域:
- 兽医微生物学 兽医微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 乳腺炎是牛奶生产动物的一个重要传染病.
- 黄金葡萄球菌 (Staphylococcus aureus) 是一个常见的乳腺炎病因.
- 黄金菌中的抗菌素耐药性对动物和公共健康构成越来越大的威胁.
研究的目的:
- 为了确定抗生素耐药性黄金葡萄球菌 (S. aureus) 在驼驼乳腺炎的流行率.
- 为了识别与乳腺炎和黄金菌感染相关的危险因素.
- 分析耐药S. aureus分离物的抗生素图和它们的遗传关系.
主要方法:
- 收集了384个驼鹿驼的牛奶样本.
- 通过微生物学程序分离和识别金黄色细菌.
- 进行了对抗甲基西林耐药的金黄色细菌 (MRSA),抗β-乳酸盐耐药的金黄色细菌 (BRSA),抗氨基糖化物耐药的金黄色细菌 (ARSA) 和抗四环素耐药的金黄色细菌 (TRSA) 的分子测试.
- 进行了抗生素耐药基因的遗传学分析.
- 评估了风险因素并进行了抗生素测试.
主要成果:
- 在177个亚临床乳腺炎病例中,从101个病例中分离出S. aureus.
- 在MRSA,BRSA,ARSA和TRSA的患病率分别为48.51%,46.53%,42.57%和39.60%.
- 确定了农场卫生,动物生理状况,乳损伤和牛奶泄漏作为重大风险因素 (p < 0.05).
- 对青素,阿莫西西林和氧化四环素观察到的耐药性最高; 列沃素显示出最敏感.
- 在体分析表明,抗性菌株的潜在跨境传播.
结论:
- 抗微生物药物耐药性黄金杆菌的高流行率,包括MRSA,在驼驼乳腺炎中.
- 鉴定出的风险因素凸显了改善农场管理和卫生实践的必要性.
- 抗微生物敏感性数据可以指导优化治疗策略,以控制驼乳腺炎并减轻AMR的传播.
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