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Updated: May 24, 2025

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在早产成年人长期高空暴露期间的氧化应激和氧化代谢反应
Marie Chambion-Diaz1, Giorgio Manferdelli2, Benjamin J Narang3
1Laboratoire Interuniversitaire de biologie de la motricité (LIBM), Université Lyon 1 Claude Bernard, Villeurbanne 69100, France; Laboratoire de kinésiologie du PEPS, Département de kinésiologie, Faculté de médecine, Université Laval, Québec G1V 0A6, Canada.
Journal of sport and health science
|February 28, 2025
概括
过早出生的成年人表现出对缺氧的抗氧化反应增强,这表明潜在的保护性预先条件效应. 它们的亲氧化酶反应看起来,表明在低氧条件下改变了氧化还原平衡调节.
科学领域:
- 生理学 生理学 生理学
- 环境医学 环境医学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 过早出生的人往往有较高的休息氧化应激.
- 过早分娩可能会对急性缺氧诱导的氧化还原变化产生抗性.
- 在低氧性缺氧状态下,研究早产者与晚产成人之间的氧化还原平衡至关重要.
研究的目的:
- 为了比较早产和早产成人的氧化还原平衡变化,在3天的低氧化暴露期间.
- 评估长期低氧对抗氧化和亲氧化酶活性的影响.
- 探索在早产的个体中潜在的缺氧预条件效应.
主要方法:
- 血液样本采集于早产和早产的成年人在normoxia和3天3375m的hypobaric hypoxia期间.
- 对抗氧化酶 (SOD,甲酶,GPx,FRAP),亲氧化酶 (XO,MPO),氧化应激标志物 (AOPP,MDA) 和氧化代谢物 (NOx,尼托铁) 的测试血.
主要成果:
- 超氧化物分离酶 (SOD) 和催化酶在低氧状态下的早产组增加.
- 亲氧化酶表现出不同的反应:XO在早产期晚些时候增加,MPO在两组都增加.
- 氧化应激标志物 (AOPP,MDA) 和甲酸在不同组之间和随着时间的推移显示出明显的变化.
结论:
- 在低氧暴露期间,早产的成年人表现出抗氧化酶的立即增加.
- 在早产的个体中,白的亲氧化酶反应表明对长期缺氧的敏感性降低.
- 这些发现支持了与早产相关的缺氧预条件效应的假设.
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