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Updated: May 24, 2025

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TREM2在髓膜动态中的作用:从生理学到病理学的全面视角

Xinwei Que1, Tongtong Zhang2, Xueyu Liu2

  • 1Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing 100053, China; Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing 100053, China; Departments of Neurobiology and Pathology, Capital Medical University, Beijing 100069, China.

Progress in neurobiology
|February 28, 2025
PubMed
概括

在骨髓细胞2 (TREM2) 上表达的触发受体会影响骨髓蛋白的健康和修复. 了解TREM2的作用对于开发用于脱髓化疾病的新疗法至关重要.

关键词:
脱乙烯化 脱乙烯化 脱乙烯化微质细胞中的微质细胞骨髓蛋白是什么意思 骨髓蛋白是什么意思在TREM2中,我们可以使用TREM2.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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