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在献血者中评估与黄金葡萄球菌鼻腔携带相关的感染风险:丹麦的一项前性多中心研究
Khoa Manh Dinh1, Kathrine Agergård Kaspersen2, Jens Kjærgaard Boldsen2
1Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
黄金葡萄球菌的鼻携带增加了黄金葡萄球菌感染的风险,特别是皮肤和软组织感染,但不是健康成年人的其他细菌感染.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 金黄色葡萄球菌 (S. aureus) 是鼻子中常见的细菌.
- 鼻腔携带S. aureus是一种S. aureus感染的危险因素.
- 鼻腔携带对其他细菌感染的影响不太清楚.
研究的目的:
- 调查黄金葡萄球菌的鼻腔携带是否会增加对黄金葡萄球菌相关感染的易感性.
- 确定鼻腔运输是否会影响健康人群中其他细菌感染的风险.
主要方法:
- 在丹麦 (2014-2021) 对8738名年龄在18至70岁的献血者进行前性队列研究.
- 金色鼻携带通过鼻子抽样确定.
- 通过国家抗菌处方和诊断登记册识别的感染终点.
主要成果:
- 40.5%的参与者是S. aureus鼻腔携带者.
- 鼻腔携带者有更高的二西林和局部酸处方的发病率.
- 携带者表现出重复二西林处方的风险更高.
- 鼻腔携带与其他抗菌药物处方或医院治疗的细菌感染之间没有发现任何关联.
结论:
- 黄金菌的鼻腔携带与与黄金菌相关的感染风险增加有关,特别是那些用二西林和酸治疗的感染.
- 鼻腔携带不会增加其他细菌感染的风险.
- 研究结果表明,鼻携带有助于增加社区获得的金菌感染的负担.
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