在患有糖尿病或糖尿病前期的人群中 Sarcopenia 和心血管疾病
Xia Wang1, Qingyue Zeng2, XiJie Yu3
1Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Journal of clinical hypertension (Greenwich, Conn.)
|February 28, 2025
概括
恶化萨科佩尼亚会增加患有糖尿病或糖尿病前期的人患心血管疾病 (CVD) 的风险. 相反,从肉症中恢复显著降低心血管疾病风险,突出显示监测肌肉质量变化的重要性.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
背景情况:
- 肉类是糖尿病或糖尿病前期患者心血管疾病 (CVD) 的已知的危险因素.
- 萨科佩尼病状况变化对心血管疾病风险的动态影响需要进一步调查.
研究的目的:
- 调查两年内萨科佩尼病状况的变化如何影响发生性心血管疾病的风险.
- 分析在糖尿病/糖尿病前患者群体中,萨科佩尼亚进展或恢复与随后心血管疾病发展之间的关联.
主要方法:
- 纵向研究设计与基线和2年后续评估.
- 通过自我报告的医生诊断 (心脏病,胸痛,心肌梗塞,心力衰竭,中风) 确定的心血管疾病事件.
- 考克斯的比例危险模型用于计算危险比率 (HRs) 和95%置信区间 (CI),调整为混因素.
主要成果:
- 与其他非sarcopenic相比,从非sarcopenia到sarcopenia的进展显著增加了心血管疾病风险 (HR 1.37,95% CI 1.08-1.73).
- 从皮病恢复到非皮病或可能的皮病降低了心血管疾病风险 (HR 0.40,95% CI 0.20-0.82) 与剩余的皮病相比.
- 从可能的sarcopenia恢复到非sarcopenia也显著降低了心血管疾病风险 (HR 0.62,95% CI 0.46-0.84) 与可能的sarcopenia相比.
结论:
- 萨科佩尼亚状态的变化显著影响糖尿病或糖尿病前期患者的心血管疾病风险.
- 恶化萨科佩尼亚与患心血管疾病的可能性更高.
- 萨科佩尼亚的恢复与心血管事件的风险降低有关,强调潜在的治疗点.
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