我们应该在重症监护营养试验中使用哪些结果?
Naomi Watson1, Saira Nazeer2, Zudin Puthucheary3
1The William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
选择正确的结果措施对于临床试验至关重要. 核心和探索性结果,包括替代结果,提高研究的一致性,并使危急疾病的早期干预成为可能.
科学领域:
- 临床试验的设计
- 生物医学研究方法的方法.
- 临界疾病研究的研究.
背景情况:
- 适当的结果测量选择对于稳健的临床试验设计至关重要.
- 核心成果集,与利益相关者的投入开发,标准化研究和支持确的建议.
- 探索性结果为疾病机制和治疗效果提供了新的见解.
研究的目的:
- 突出临床研究中核心和探索性结果的重要性.
- 强调替代结果在危急疾病早期干预方面的潜力.
主要方法:
- 对临床试验结果测量措施选择原则的审查.
- 讨论利益相关者在定义核心成果集中的贡献作用.
- 探索探索和替代结果的实用性.
主要成果:
- 核心成果集提高了研究的一致性,并促进了最终的结论.
- 探索性结果提供了对疾病病理生理学和治疗反应的更深入的理解.
- 替代结果的发展可以导致更早的,潜在的预防性干预.
结论:
- 整合核心和探索性结果优化了临床试验设计.
- 替代结果对危急疾病的积极管理具有前性,将重点从后果管理转移到预防.
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