多发性硬化症的流行病学,病理学和致病性:治疗影响
1University of California, San Francisco and the San Francisco VA Medical Center, 675 Nelson Rising Lane, Suite #221D, San Francisco, CA 94158, USA.
概括
多发性硬化症 (MS) 是一种慢性中枢神经系统炎症性疾病. 一个随机事件,以及遗传和环境因素,影响着MS的发病和女性患病率的增加.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 多发性硬化症 (MS) 是一种慢性,炎症性中枢神经系统 (CNS) 疾病.
- 多发性硬化包括不可预测的神经功能障碍和多焦点中枢神经系统组织损伤.
- 与男性相比,女性受MS的影响不成比例,比率为2-3:1.
研究的目的:
- 审查当前对多发性硬化病原学的理解.
- 探索MS的流行病学,病理学和遗传学.
- 讨论对当前和未来MS管理的治疗影响.
主要方法:
- 关于多发性硬化病原学的文献综述.
- 对MS患病率的流行病学数据的分析.
- 对MS的遗传和环境因素的检查.
- 讨论MS治疗策略的讨论.
主要成果:
- 多发性硬化症的发病包括遗传,环境和随机机制.
- 随机事件被认为是导致女性多发性硬化症患病率增加的原因.
- 目前的多发性硬化疗法和未来的治疗方法都受到病原遗传机制的影响.
结论:
- 了解多发性硬化症的发病因子对于有效的管理至关重要.
- 未来的疗法可能会针对特定的病原遗传途径.
- 对随机事件在MS中的作用进行进一步研究是有必要的.
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