客观化COVID-19感染后持续的主观认知障碍:来自德国门诊记忆诊所的横截面数据
Luca Tarantini1, Corina Möller2, Victoria Schiestl2
1Department of Psychiatry and Psychotherapy, Saarland University Medical Center, Kirrberger Straße, Building 90, 66421, Homburg, Germany. luca.tarantini@uks.eu.
European archives of psychiatry and clinical neuroscience
|February 28, 2025
概括
后COVID认知问题更多与抑郁症有关,而不是客观障碍. 评估抑郁症和APOE-ε4基因型对于了解长期COVID患者的认知缺陷至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 传染性疾病 传染性疾病
背景情况:
- 主观认知障碍是患有COVID后疾病的个体中常见的抱怨.
- 对注意力,记忆力和执行功能的客观认知缺陷需要彻底评估.
研究的目的:
- 评估COVID-19后主观认知能力下降的患者的客观认知障碍.
- 确定客观认知障碍的预测因素,包括抑郁症和遗传因素.
主要方法:
- 一项涉及229名COVID后患者的主观认知障碍的横截面研究.
- 标准化神经心理测试 (维也纳测试系统),精神病学评估和心理测量评估 (BDI-II,FSS).
- 对免疫标记物 (IL-6,CRP) 和APOE-ε4基因型的血液样本进行分析.
主要成果:
- 39%的患者在至少一个领域表现出客观认知障碍.
- 47%的患者报告中度至严重的抑郁症状.
- 抑郁症状 (OR=1.41) 和APOE-ε4等位基因 (OR=3.29) 显著预测了客观认知障碍,独立于其他因素.
结论:
- COVID-19后的主观认知障碍与抑郁症的关联比客观认知缺陷更强.
- 神经心理学测试和抑郁症查对于后COVID患者至关重要.
- 认知障碍,抑郁症和APOE-ε4之间的观察到的联系表明潜在的神经退行性途径可能是治疗目标.
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