特定的认知障碍预测了轻度认知障碍患者的神经精神症状
Chenxi Pan1,2, Ningxin Dong3, Xiao Yuan1,2
1Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Putuo District, Shanghai, 200092, China.
Aging clinical and experimental research
|February 28, 2025
概括
神经精神症状 (NPS) 影响了超过一半的轻度认知障碍 (MCI) 患者,经常表现为抑郁或焦虑. 这些症状与较差的认知功能相关,可能需要早期干预.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 神经精神症状 (NPS) 在轻度认知障碍 (MCI) 中很普遍,但它们与临床因素和认知表现的特定关联仍未得到充分研究.
- 了解这些关系对于管理MCI和潜在地预防发展为痴呆症至关重要.
研究的目的:
- 调查MCI患者中NPS的流行情况.
- 检查MCI中NPS,临床因素 (如缺血性心脏病) 和认知领域 (记忆,语言,注意力) 之间的关系.
- 为了确定MCI中NPS的预测因素.
主要方法:
- 分析了Tongji老龄化队列研究的数据,包括1323名MCI参与者,1099名痴呆症患者和377名认知正常 (CN) 个体.
- 进行了全面的临床和神经心理评估.
- 神经精神病学库存问卷 (NPI-Q) 用于评估NPS,后勤回归分析发现了显著的关联.
主要成果:
- 在56.39%的MCI参与者中存在NPS,抑郁,焦虑,冷漠和易怒是最常见的.
- 与没有NPS的患者相比,患有MCI的NPS患者在全球,记忆,语言和注意力领域表现较差.
- 缺血性心脏病与MCI中NPS的可能性更高 (OR=1.41),而更好的记忆 (OR=0.847) 和语言 (OR=0.801) 功能与更低的可能性相关.
结论:
- NPS在MCI中很常见,并且与语言和记忆功能的缺陷有显著联系.
- 确定与NPS相关的特定认知障碍可以帮助临床医生专注于MCI患者的早期检测和干预策略.
- 在MCI中早期关注NPS可能对患者管理和潜在地减轻认知衰退至关重要.
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