与多发性硬化症相比,在髓寡基细胞糖蛋白-IgG相关疾病中的认知结果
Eileen Galvani1, Jeffrey A Cohen2, John T Martin3
1Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Brain and behavior
|February 28, 2025
概括
认知功能障碍常见于患有髓寡腺细胞糖蛋白-IgG相关疾病 (MOGAD) 的患者. 在处理速度和记忆方面发现了客观缺陷,类似于多发性硬化症 (MS).
科学领域:
- 神经免疫学 神经免疫学
- 神经科学是一个神经科学.
- 认知神经学 认知神经学
背景情况:
- 髓寡细胞糖蛋白-IgG相关疾病 (MOGAD) 是一种自身免疫性疾病,对其认知影响的理解有限.
- 虽然与多发性硬化症 (MS) 有相似之处,但MOGAD中不同的认知特征需要调查.
研究的目的:
- 评估MOGAD成年人的主观和客观认知结果.
- 为了比较MOGAD (pwMOGAD) 患者和MS (pwMS) 患者之间的认知表现.
主要方法:
- 在pwMOGAD中对主观认知变化的回顾性审查.
- 认知查和综合性神经心理测试用于pwMOGAD的子集.
- 与年龄,性别和种族匹配的pwMS进行pwMOGAD性能比较,比率为3:1.
主要成果:
- 超过一半 (51.6%) 的pwMOGAD报告认知功能障碍.
- 在pwMOGAD和pwMS之间处理速度选分数没有显著差异.
- 在pwMOGAD测试中,57%的人至少在一个认知领域表现出损伤,36%的人在两个或更多的认知领域表现出损伤,与pwMS相比.
- 缺陷在处理速度,口语流,空间判断和即时回忆方面最为普遍.
- 在视觉运动处理速度和认知灵活性方面,PwMOGAD表现比pwMS更好.
结论:
- 在pwMOGAD中,主观认知抱怨和客观缺陷是常见的.
- 临床上显著的认知障碍影响了大约三分之一的pwMOGAD.
- 处理速度,语言流,空间判断和单词列表回忆是MOGAD认知缺陷的常见领域.
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