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Updated: May 24, 2025

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

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通过PAICS乙化,ACSS2通过限制精氨酸生物合成来驱动与衰老相关的分泌表型

Li Yang1, Jianwei You2, Xincheng Yang1

  • 1Research and Innovation Center, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, 201203, China.

Nature communications
|February 28, 2025
PubMed
概括

这项研究表明,ACSS2抑制会抑制与衰老相关的分泌表型 (SASP) 和其有害影响. ACSS2通过控制PAICS乙化来调节SASP,影响 purin代谢和细胞功能.

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Techniques to Induce and Quantify Cellular Senescence

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Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

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