晚期糖化终端产品在甲状腺功能和糖尿病病和代谢障碍之间的作用
Yi Zhang1, Yanlei Wang2, Qingqing Kang2
1Department of Endocrinology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. zy18356056506@163.com.
先进的糖化终产品 (AGEs) 和甲状腺刺激激素 (TSH) 显著影响糖尿病病 (DN). 优化TSH管理和监测AGE可以帮助预防和治疗DN,特别是在健康风险高的患者中.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 糖尿病病 (DN) 是糖尿病的一个主要并发症,导致显著的发病率和死亡率.
- 先进的糖化终产物 (AGEs) 和甲状腺刺激激素 (TSH) 与代谢疾病有关,但它们在DN中的相互作用尚未完全理解.
- 本研究研究了AGE,TSH,代谢指标和DN之间的关系,以告知未来的干预措施.
研究的目的:
- 研究AGE,TSH,代谢指标和糖尿病病 (DN) 之间的关系.
- 为未来旨在预防和管理DN的干预提供证据.
- 探索健康风险因素对TSH-AGEs-DN轴的缓和作用.
主要方法:
- 从2018年3月到2022年7月,安省的社区卫生中心和医院采用了多阶段的集群采样方法.
- 血液样本分析了TSH,脂质,葡萄糖和肝/功能. 通过皮肤自光 (SAF) 来测量AGE,并评估尿中的白蛋白与肌素比率 (ACR).
- 使用单向ANOVA比较数据,并进行关联分析以确定变量之间的关系.
主要成果:
- 在最初选择的7000名参与者中,最终分析包括了6921名 (94.4%的有效率).
- 包括BMI,TSH,LDL,TyG指数,SBP,TC和UA在内的健康风险因素与尿液ACR升高的更高发病率有关.
- 调节分析显示,TSH和AGE对DN有显著影响,健康风险因素也调节了这些关系.
结论:
- 优先考虑HDL,TyG和TC等健康风险因素对于降低高风险中国患者的DN至关重要.
- 综合性指标评估可以有效地评估DN的代谢进展.
- 优化甲状腺功能管理和了解AGE的作用可能为DN预防和治疗提供新的策略,特别是在TSH调节方面.
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