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Updated: May 24, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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连接体有效性将核受体构成组合在转录活性和抑制状态之间转移

Brian S MacTavish1, Di Zhu2, Jinsai Shang1,3

  • 1Department of Integrative Structural and Computational Biology, Scripps Research and The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.

Nature communications
|February 28, 2025
PubMed
概括

研究人员开发了一种新型的带系列,用于过氧体增殖器激活受体玛 (PPARγ),可以在激活和抑制功能之间切换. 这一发现增强了对核受体动力学和反向激励机制的理解.

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