妊娠间隔和早产之间的关联:系统性审查和元分析
Xueheng Wen1,2, Weilun Liang3, Jinguo Zhai4
1School of Nursing, Southern Medical University, 1023 Shatai South Road, Baiyun District, Guangzhou City, 510515, Guangdong Province, China.
BMC pregnancy and childbirth
|February 28, 2025
概括
24-29个月的最佳妊娠间隔 (IPI) 显著降低了早产风险. 这一发现为计划生育和临床指导提供了一个目标范围,以改善分娩结果.
科学领域:
- 产科和妇科 产科和妇科
- 生殖健康 生殖健康
- 围产期流行病学 围产期流行病学
背景情况:
- 妊娠间隔 (IPI) 与早产有关,但最佳持续时间需要进一步阐明.
- 现有的研究表明,妊娠间隔和不良分娩结果之间存在关联,需要进行全面的审查.
研究的目的:
- 系统地审查和元分析各种妊娠间隔对早产风险的影响.
- 确定最佳的妊娠间隔,以减少早产的发生率.
主要方法:
- 在主要数据库 (PubMed,Cochrane,Web of Science,Embase) 进行了系统的文献搜索,截至2023年6月2日.
- 包括的研究使用纽卡斯尔-太华尺度 (NOS) 进行了质量评估.
- 用贝叶斯网络的元分析来合成数据,并评估IPI和早产之间的关联.
主要成果:
- 对34项涉及8,646,679人研究的分析确定了24-29个月的最佳IPI.
- 与<5个月的间隔相比,这种间隔与早产风险 (<32周妊娠[OR=0.55;95%CI:0.50-0.62]) 和 (<37周妊娠[OR=0.61;95%CI:0.59-0.63]) 的显著降低有关.
结论:
- 24-29个月的妊娠间隔与早产风险的显著降低有关.
- 这些发现表明一个特定的间隔范围,可以针对计划生育和临床建议,以改善母亲和婴儿的结果.
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