泌尿功能,性功能和前列腺低剂量治疗后的生活质量:一个回顾性分析
Lauri Mäkelä1, Arto Mikkola2, Anssi Pétas2
1Comprehensive Cancer Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. lauri.makela@hus.fi.
BMC urology
|February 28, 2025
概括
针对前列腺癌的低剂量率支臂治疗在大多数患者中会引起暂时的尿路副作用. 患者报告的结果显示过渡性尿路功能障碍,强调讨论潜在副作用的重要性.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 辐射瘤学 辐射瘤学
背景情况:
- 局部性前列腺癌提供治愈治疗选择.
- 低剂量率支臂治疗 (LDR-支臂治疗) 是一种有效的前列腺癌治疗方法.
- 医生评估的毒性可能无法完全捕捉患者的副作用经验.
研究的目的:
- 用患者报告的结果来评估LDR-brachytherapy的尿路副作用.
- 将患者报告的结果与尿功能的客观测量进行比较.
主要方法:
- 对199名接受LDR-brachytherapy治疗的患者进行了回顾性研究 (2000 - 2012年).
- 通过国际前列腺症状评分 (IPSS) 和丹麦前列腺症状评分 (DAN-PSS) 评估尿道毒性.
- 用国际勃起功能指数 (IIEF) 评估性功能和用尿液流量计评估尿功能.
主要成果:
- 在LDR-brachytherapy后的前六个月里,尿功能下降.
- 大多数尿路副作用都是短暂的,得分在一年内恢复到基线.
- 患者报告的结果和尿液流量测试结果之间存在小差异.
结论:
- 在局部性前列腺癌中,LDR-brachytherapy通常被很好地容忍.
- 急性尿路副作用很常见,但通常很快就会消失.
- 长期副作用的小风险需要与患者进行彻底的讨论.
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