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Updated: May 24, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Published on: March 27, 2020

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PPARα通过影响其无化修饰来调节YAP蛋白水平和活性

Wenhong Zhou1,2, Shuaishuai Zhang1, Yao Chen1

  • 1NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.

BMC biology
|February 28, 2025
PubMed
概括

过氧体增殖器激活受体α (PPARα) 的激活减少了YES相关蛋白 (YAP) 的总体泛基化,促进了其核转位和活性. 这项研究揭示了PPARα调节YAP无化,影响肝脏生长和再生.

关键词:
Peroxisome增殖器激活的受体 α 是一个受体.在TRAF6中,在Ubiquitination中使用.是的 - 相关蛋白质.

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