严重膝关节骨关节炎的女性患者的大腿肌肉特征:一个横截面研究
Tingting Liu1, Hao Xie1, Songhua Yan1
1School of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Fengtai District, Beijing, China.
BMC musculoskeletal disorders
|February 28, 2025
概括
女膝关节骨关节炎患者表现出显著的肌肉损失和改变的机械特性,影响关节功能. 双股长头肌的特征是这些患者膝关节功能的关键预测因素.
科学领域:
- 肌肉骨成像检查 肌肉骨成像检查
- 生物机械分析分析
- 骨关节炎的研究研究.
背景情况:
- 在女性中,严重的膝关节关节炎 (KOA) 与肌肉功能受损有关,原因是肌肉形态,组成和机制的变化.
- 这项研究调查了女性KOA患者的大腿肌肉特征及其与膝盖功能之间的关系.
研究的目的:
- 评估严重KOA的女性患者的大腿肌肉特征 (PCSA,EI,G).
- 探索这些肌肉特征与膝关节功能之间的相关性.
主要方法:
- 超声波和剪切波弹性图学用于测量24名KOA患者和24名对照者的大腿肌肉中的生理横截面积 (PCSA),回声强度 (EI) 和剪切模量 (G).
- 群体之间的肌肉特征进行了比较,并分析了与膝关节功能得分 (WOMAC,KSS,HSS) 的相关性.
主要成果:
- 与对照组相比,KOA患者在多个大腿肌肉中显示PCSA降低,EI升高 (表明肌内脂肪),G值更高 (表明硬).
- 双股长头 (BFL) 肌肉的PCSA和G,以及半 (ST) G和大 (VM) EI,与膝关节功能得分有显著的相关性.
- 在所有评估的膝盖功能得分中,BFL的PCSA和G被确定为最重要的预测因子.
结论:
- 与对照人群相比,KOA患者表现出显著的肌肉损失 (PCSA降低高达22%),肌肉硬度增加 (20.65%高于G),肌肉内脂肪增加 (高达23.88%高于EI).
- 这些肌肉变化 (G,PCSA,EI) 与膝关节功能密切相关.
- BFL肌肉的PCSA和G是膝关节功能最重要的预测指标,为KOA肌肉功能障碍提供了洞察力.
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