冠状动脉对扩张性功能障碍的进展的影响:一个队列研究
Ki Hong Choi1, Danbee Kang2,3, Seung Hun Lee4
1Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, 06351, Republic of Korea.
BMC medicine
|February 28, 2025
概括
高冠状动脉 (CAC) 水平与更高的发病率和更快的扩张性功能障碍 (DD) 相关. 这种组合在一般人群中显著增加死亡风险.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 医疗成像医学成像
背景情况:
- 冠状动脉 (CAC) 与腹功能障碍 (DD) 进展之间的联系尚不清楚.
- 调查CAC和DD对死亡率的综合影响至关重要.
研究的目的:
- 根据CAC的严重程度来检查DD的患病率和进展情况.
- 确定CAC和DD对所有原因死亡率的协同效应.
主要方法:
- 基于人口的队列研究,对15,193名成年人进行了同时进行心声回声和CAC扫描.
- 确定的确定的DD (≥3/4异常参数) 和确定的或可能的DD (≥2/4).
- 评估了与CAC和DD状态相关的全因死亡率.
主要成果:
- 较高的CAC分数 (≥100) 与确定的和可能的DD的患病率增加有关.
- 在CAC严重程度和E/e'比率之间观察到显著的线性关联.
- 增加的CAC (≥100) 和DD独立和协同增加死亡风险.
- 显著的CAC (≥100) 预测了DD进展的加速和随着时间的推移更快的E/e'升高.
结论:
- 在一般人群中,CAC和DD的患病率之间存在显著的关系.
- CAC和DD都是增加死亡率的独立预测因素.
- CAC ≥100显著驱动DD进展,独立于其他临床因素.
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