适用于非饮食暴露的累积风险评估方法:在职业农业环境中的发展变化
Luca Tosti1, Martina Marazzini2, Mohammed Kanadil2
1Department of Biomedical and Clinical Sciences, University of Milan, International Centre for Pesticides and Health Risk Prevention ASST Fatebenefratelli Sacco, Milan, Italy.
Journal of occupational medicine and toxicology (London, England)
|February 28, 2025
概括
本研究探讨农业工人非饮食性农药暴露的累积风险评估 (CRA). 调查结果表明,电子治疗登记册对于评估现实生活中的暴露和为未来的风险评估提供信息非常有价值.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 风险评估 风险评估
背景情况:
- 对异生菌的联合暴露需要进行严格的安全评估.
- 目前的累积风险评估 (CRA) 主要关注饮食中的农药暴露,忽视了农业专业人员的重大非饮食风险.
- 欧盟缺乏非食性CRA的协调方法,尽管有立法承认.
研究的目的:
- 探索将CRA方法应用于农业环境中非食性农药暴露的可行性.
- 评估植物保护处理的电子登记册作为非食CRA的数据来源的实用性.
- 估计农业经营者,重新入境工人和旁观者的累积非饮食系统暴露.
主要方法:
- 利用植物保护处理的电子登记册来识别田间农药混合物.
- 由EFSA建立的胎儿面变化累积评估小组 (CAG) 选择的活性物质.
- 采用欧盟认可的数学模型来估计农药暴露.
主要成果:
- 电子登记册对于在专业农业环境中评估实际植物保护产品 (PPP) 的使用非常有价值.
- 初步发现支持使用饮食CRA方法进行非饮食风险评估的可行性.
- 该研究确定了未来非饮食风险评估的关键数据来源和方法.
结论:
- 治疗的电子注册是一个可行的和有价值的数据来源,用于农业的非食累积风险评估.
- 该研究为调整饮食CRA方法以评估非饮食农药暴露风险提供了基础.
- 需要进一步的研究,以将这种方法扩展到与CAG相关的其他急性和长期影响.
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